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What is a PD-L1 antibody?

Programmed death receptor-ligand 1 (PD-L1 B7-H1) is a newly identified B7 family member of the B7 family. So far, only one receptor was identified that could be ligated with PD-L1.  

This receptor, known as programmed death receptor 1 (PD-1) is believed to be demonstrated to negatively regulate the T-cell receptor (TCR) signaling. After ligating its receptor it has been shown to reduce TCR-mediated proliferation as well as the production of cytokine.  You can know more about PD-L1 antibodies via

PD-L1 Monoclonal Antibody- CUSABIO

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The expression of PD-L1 was observed to be high on a variety of human and murine cancers and may be further regulated when IFN-gamma stimulation is applied. This suggests that PD-L1 may be a key factor in the evasion of the tumor-immune system.

An important immune checkpoint is activated by PD-1 (programmed cells death protein) is activated by its ligand PD-1. Because of this interaction, cell activation is reduced while an active immune reaction is prevented.

This process is usually embraced by cancerous tumors. The PD-L1 gene is elevated in a variety of kinds of tumors and plays a role in cancerous tumors through interaction with PD-1 and preventing T cells' activation. 

By doing this, tumors are not detected and destroyed by the immune system. Therefore, PD-1 and PD-L1 have been the subject of much interest due to their role in the field of immunology of tumors as well as in the field of immune-based therapeutic targets.